A 2016 study published in the Journal of the American College of Surgeons was able to show that genetics play a role in the presence of varicose veins. In order to determine whether genetics was a cause, the researchers used Swedish-born adoptees that could be traced back to both their biological and their adopted parents. The study found that there was an increase risk of varicose veins in adoptees with an affected biological parent but an unaffected adopted parent compared to adoptees with an unaffected biological and adopted parent. Further, the study found that the risk was even higher for adoptees in which both the biological parent and adopted parent were affected. Finally, the study showed that there was not an increased risk in adoptees with an unaffected biological parent and an affected adopted parent. Therefore, this study shows the important role genetics play in the presence of varicose veins, and also indicates that familial environments could play a role as well.
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Kohno, K., H. Niihara, X. Li, T. Hamano, T. Nabika, K. Shiwaku, M. Isomura, E. Morita, K. Sundquist, and B. Zöller. "Familial Transmission of Hospital-Treated Varicose Veins in Adoptees: A Swedish Family Study." Journal of the American College of Surgeons 223.3 (2016): 452-60. Medscape. WebMD LLC. Web. 19 June 2017.